نام كاربري
كلمه ورود
درخواست عضویت
کلمه ورود را فراموش کرده ام

صاحب امتیاز:جامعه جراحان ایران
مدیر مسئول:دکتر ایرج فاضل
سردبیر: دکتر مصطفی جابـرانصاری
مدیر اجرایی:دکتر شیوا گلشنی

آدرس:تهران - دفتر مرکزی جامعه جراحان ایران-خیابان میرداماد- شماره 175-
کد پستی:1919913961
تلفن:30-26401420
دورنگار:22271119
پست الکترونیک:info@ijs.ir

صفحه نخست :: بخش مدیریت نشریهصفحه قبل

Journal Title: بهار 1400
Article title: Fabrication and Characterization of Bilayer Wound Dressing Polyurethane- Gelatin/ Polycaprolactone for Usage in Tissue Engineering

Article PDF File:
Page From: 57 To: 68      

Article abstract:
Introduction & Objective: Infection is one of the main causes of delayed wound healing. In addition to infection, in some chronic wounds, such as diabetic wounds, the wound heals slowly due to reduced angiogenesis. For this purpose, a two-layer dressing consisting of gelatin / polycaprolactone nanofibers and polyurethane film can be a suitable solution to accelerate wound healing. Materials & Methods: In order to make double-layer polyurethane - gelatin / polycaprolactone nanofiber dressing. Solution of Polyurethane (12%W/v) in tetrahydrofuran / dimethyl formamide is first placed on a magnetic stirrer. After the formation of a uniform solution, the solution is formed on Teflon molds in order to prepare a film by solvent casting. The polycaprolactone / gelatin polymer solution is then prepared at ambient temperature at a concentration of 10% by weight, and finally the fibers are spun randomly onto the fabricated polyurethane film. Results: The morphology of the bilayer dressing was examined by scanning electron microscopy. Tests such as water absorption, mechanical properties (fracture strain and tensile strength), contact angle and cytotoxicity were performed. The contact angle test for polycaprolactone and polycaprolactone / gelatin nanofibers was measured at 114 and 44 degrees, respectively. Tensile strength for double-layer scaffolding was 4.46 MPa and fracture strain was reported at an average of 330%. Cytotoxicity test showed that the samples were not toxic. Fibroblast cells also showed good adhesion to the dressing. Conclusions: The results of studies showed that double layer dressing can be a suitable solution for the treatment of diabetic infectious wounds also Skin Tissue Engineering.

Article KeyWords:
Polyurethane, Gelatin, Polycaprolactone, Skin Tissue Engineering

Article Authors:
مهندس آیسان هدایت نظریFirst Author
دکتر مهدی موحدیOther Authordr.mehdimovahedi@gmail.com
مهندس مهیار ناصریOther Author




بالای صفحه
صفحه اصلی  |  تماس با ما  |  آرشیو مجله  |  نقشه سایت  |  عضویت  |  ارسال مقاله  |  پیگیری مقاله

استفاده از مطالب این سایت با ذکر نام سایت مجاز می باشد   -   Copyright © 2007, 2009 - Last Update 5-11-2009
Powered By www.itpco.net    www.itpco.ir
( ITPCO ) شرکت توسعه انفورماتیک ایران
تولید کننده سیستم های تخصصی مدیریت نشریات و همایش ها و مورد تائید کمیسیون نظارت بر نشریات پزشکی وزارت بهداشت درمان و آموزش پزشکی کشور