Journal Title: تابستان 94
Article title: Study of the Effect of Autologous Spleen Transplantation in Patients, who had Splenectomy because of Severe Splenic Lesions due to Trauma, and who Referred to Besat Hospital during 2013-14
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Page From: 57 To: 65
Introduction & Objective: Previously it was thought that spleen is not an important organ with special function. Therefore the elected treatment of spleen diseases has been full splenectomy. By greater recognition of the spleen function and its important role in the body physiology, it was found that full splenectomy causes immunocompromised increasing in the individuals and made them prone to certain infections and the risk of tromboemboli. The present study was conducted for precise analysis of the immune system changes, including immunoglobulin levels with regard to the study of tissue changes and the regeneration of the transplanted spleen, in order to achieve proper performance with the hope of reducing the complications of inevitable splenectomy especially due to post-traumatic ones.
Materials & Methods: In an interventional and cross-sectional study, 19 patients over 12 years old with blunt trauma, who, were suffering from severe splenic blunt trauma in 2013/14, based on the treating physician’s diagnosis were full splenectomy candidates, came under our study. Patients with census and giving written consent were included in study. After the approval of the patient Candidacy for of splenectomy, necessary explanations were provided to the patients and lack of exclusion criteria, patients were evaluated and eventually graft surgery was performed on them. Finally, all the patients’ informations were entered into SPSS version 16 and were analyzed. Measures of central tendency and dispersion (mean and standard deviation) of charts and graphs were used for data analysis in descriptive statistics. In inferential statistics, repeated measures test were used and in case of abnormal data its equivalent Friedman test were used.
Results: In the present study, a total of 19 patients with an average age of 42.58±18.78 years old of which 14 (%73.7) were male, were studied. The results of the univariate analysis showed a statistically significant difference (P=0.024) in the rate of lymphocyte over time (before the surgery, 3 months after the surgery and 6 months after the surgery). However the variables hemoglobin (P=0.192), red blood cells (P=0.177), hematocrit (P=0.192), platelets (P=0.221), and leukocytes (P=0.071) revealed no significant difference. The presence or absence of Howell bodies indicated a significant difference (P=0.042), over time so that the Howell bodies in the 6 months before surgery were less than 3 months after surgery. The difference between average spleen phagocytic at 3 months after surgery and 6 months after surgery was significant (P=0.044). In fact, the average spleen phagocytic at 6 months after the surgery was higher than that of 3 months after the surgery.
Conclusions: Based on the results of this study, by increasing the time as well as transplanted chips, the difference between the individuals with auto transplanted spleen and those with healthy spleen can be reduced to the lowest possible rate. Auto transplantation of Spleen has been proved to be a very appropriate alternative therapy to splenectomy.
Splenectomy, Trauma, Spleen
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