Journal Title: زمستان 93
Article title: Comparison of Lateral Internal Sphincterotomy and Botulinum Toxin Injection in Treatment of Chronic Anal Fissure

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Page From: 28 To: 34      
Article abstract:
Introduction & Objective: Chronic anal fissure is one of the most common anorectal diseases. Most patients recovered by conservative treatments. But the disease is chronic if clinical manifestations lasts more than six weeks. Sphincterotomy is known as the treatment of choice for chronic anal fissure, although it is associated with long-term potential complications. Flatus and fecal incontinence, infection, and persistent pain are uncomfortable side effects that may occur in 0.35 of patients undergoing sphincterotomy. Materials & Methods: In a randomized clinical trial, 86 patients with chronic anal fissure were randomly divided into two groups. Eligible patients were divided into two groups: the first group were treated with 60 unit of Dysport injected into the internal anal sphincter, and the second group underwent lateral internal sphincterotomy. Then the rate of recovery and postoperative complications, such as pain, bleeding and recurrence or other complications were compared during the 3-month follow-up. Results: Two weeks after the treatment, the recovery rate was 100% (86 patients), from which 19 patients (22.09%) had partial improvement and 67 (77.91%) had complete recovery. The complete recovery rate in the two study groups of PLIS and disport injection were (36 cases) 83.72% and (31 cases) 72.09% respectively. The relative recovery rate in the two groups, were 16.28% and 27.91%, respectively (P=0.194). In 3 months follow-up after the treatment, the complete recovery rate in the two groups of PLIS and disport injection groups were (36 cases) 83.72% and (31 cases) 72.09% respectively. The relative recovery rate in the two groups were respectively (4 cases) 9.3% and (3 cases) 6.98%. The recurrence rate between the two groups of PLIS and disport injection groups were respectively (3 cases) 6.98% and (9 cases) 20.93%. The difference between the recovery rate and recurrence rate, 3 months after the treatment in both groups was not significant (P=0.059). The mean duration of pain for the disport injection and PLIS were respectively 6.77±2.02 and 11.98±2.48 days, (P
Article KeyWords:
Chronic anal Fissure, Lateral Internal Sphincterotomy, Botulinum Toxin Injection
Article Authors:

	دکتر حمید رضا خورشیدی	First Author
	دکتر امیر درخشان فر	Other Author	dr_derakhshanfar_a@yahoo.com
	دکتر حمیدرضا فریدونیان	Other Author
	دکتر امین نیایش	Other Author