Journal Title: زمستان 87 Article title: Evaluation of the Effect of Oral Clonidine in the Prophylaxis of Nausea and Vomiting in Elective in Adult Orthopedic Surgery of Limb
Article PDF File: Page From: 35 To: 41
Article abstract: Introduction & Objective: Post operative nausea and vomiting (PONV) is regarded as important post operative complications that leads to reducing patients satisfaction and other complications such as aspirations pneumonia, wound dehiscence and delay in discharge the patient. Several drugs have been examinated for diminishing this complication during the past few years. In this study we compared the efficacy of oral clonidine in the prevention of PONV in two groups.
Materials & Methods: This was a double blind randomized clinical trial performed on 160 patients who were candidate for elective limb orthopedic surgery at Khatam al-Anbia' (sal) hospital Zahedan, Iran at 2007.
The patients were randomly grouped into two 80 member groups. The 1st groups was given 0.1 mg oral clonidine and the 2nd groups was given placebo 45 min before surgery. Then they underwent similar standard anesthetic methods and the follow up was done in recovery room and then in the orthopedic department for maximum of 24 h after surgery. The prevalence of PONV in the two groups was compared through statistical tests.
Results: The results of this study in the two groups demonstrated a statistically meaning full difference between the prevalence of PONV in the two groups (P<0.0001). Side effects in both groups were equally rare.
Conclusions: Using a low dose of oral clonidine can significantly increase the change of PONV free orthopedic surgeries.
Article KeyWords: Clonidine, Post Operative Nausea and Vomiting (PONV), Orthopedic Surgery
