Journal Title: تابستان 95
Article title: Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas
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Introduction & objective: The third common primary intracranial tumors are pituitary adenomas. Atypical pituitary tumors are characterized by MIB-1>3% & significant P53 nuclear staining. The aim of this study is to evaluate the relationship of the mutant P-53 & MIB-1 level with the outcome of these tumors.
Materials & Methods: This Cohort study is conducted in both retrospective & prospective phases from April 2013 to October 2015, 83 patients were enrolled, and inclusion criteria were presence of radiological, clinical or endocrinologic evidence of functional or non-functional pituitary adenomas. Besides, all the patients underwent surgery, whether trans-sphenoidal or trans-cranial, for evacuation of adenomas. Follow-up radiologic and clinical evaluation were done 6 weeks, 6months, and one year after the surgery in all the cases.
Results: The non-functional tumors were significantly more aggressive (82.2% versus 55.3% in functional adenomas) (P=0.008). No significant relationship was found between outcome MIB-1 & P53 levels (P=0.49, P=0.834 respectively). On the other hand, invasiveness was significantly related to outcome (39 patients (84.7%) with unaccepted outcome and 19 (51.3%) cases with accepted outcome were invasive, P=0.001).
Conclusions: Among invasiveness & MIB-1 & P-53 level, the role reliable prognostic factors for anticipating the outcome seems to be invasiveness and the other factors can be just assumed as confounder factors.
Pituitary Adenoma, MIB-1, P-53
|دکتر محمد شیرانی بیدآبادی||First Author|
|دکتر عباس امیرجمشیدی||Other Author||abamirjamshidi@Yahoo.com|
|دکتر کوروش کریمی یارندی||Other Author|
|دکتر هدیه مرادی تبریز||Other Author|
|دکتر سیدمحمد حسینی||Other Author|
|دکتر سیدشهاب قاضی میرسعید||Other Author|