Journal Title: زمستان 88 Article title: Comparison between Immunohistochemistry and Chromogenic in Situ Hybridization Method in Assessment of HER-2 Status in Breast Cancer
Article PDF File: Page From: 41 To: 48
Article abstract: Introduction & Objective: The epidermal growth factor receptor gene (HER-2) plays an important role in cell transformation and tumorgenesis. The presence of HER-2 gene generally predicts a good response to anthracycline-based agents and therapies that specifically target HER-2 (Herceptin).
Materials & Methods: Comparison between IHC and CISH methods for assessment of HER-2 status was performed on 38 women suffering from invasive ductal carcinoma. Data analysis was performed by pair wise grouped statistical method.
Results: There was a good correlation between IHC and CISH methods for assessment of HER-2 status in 92.1% of cases (Kappa=0.938, P
Article KeyWords: Breast Cancer, Epidermal Growth Factor Receptor, Immunohistochemistry, Chromogenic in Situ Hybridization
