Comparison of Efficacy of Local Piroxicam and Diclofenac in Benign Mastalgia

Document Type : Original Article

Authors

1 Assistant Professor of General Surgery, Resident of Thoracic Surgery, Lorestan University of Medical Sciences and Health Services, Shohadaye Ashayer Hospital, Lorestan, Iran

2 Associate Professor of Pharmrcology, Lorestan University of Medical Sciences and Health Services, Shohadaye Ashayer Hospital, Lorestan, Iran

3 Methodologist and Research Advisor, Lorestan University of Medical Sciences and Health Services, Lorestan, Iran

4 Assistant Professor of General Surgery, Lorestan University of Medical Sciences and Health Services, Shohadaye Ashayer Hospital, Lorestan, Iran

5 Assistant Professor of Thoracic Surgery, Esfahan University of Medical Sciences and Health Services, Al-Zahra Hospital, Esfahan, Iran

6 General Practitioner, Lorestan University of Medical Sciences and Health Services, Shohadaye Ashayer Hospital, Lorestan, Iran

7 Resident of Thoracic Surgery, Esfahan University of Medical Sciences and Health Services, Al-Zahra Hospital, Esfahan, Iran

Abstract
Introduction & Objective: Breast pain is a common disorder affecting up to 70% of women during their life. Although most of these women can be managed by reassurance alone, a significant number still require medical treatment. Topical Non - Steroidal Anti Inflammatory Drugs (NSAIDs) are established as having a palliative effect on mastalgia. Materials & Methods: A clinical trial study of Piroxicam gel versus Diclofenac gel was carried out, over a period of one year. Fifty female patients attending the outpaint department with severe breast pain were given one of the two agents alternatively, after selection. Results: The results show that out of 25 patients treated with diclofenac gel, 60% had a clinically significant response after two months of treatment, compared with, 92% with Pyroxicam gel. Only one patient (4%) had side effect with Diclofenac gel. Conclusions: Piroxicam gel application is more effective, safe and acceptable treatment compared with disolfenac gel for sever cyclic mastalgia.

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