Introduction & Objective: Considering the increasing rate of varicocele disease, the choice of anesthesia for suitable surgical condition and rapid recovery and minimal side effects is very important. This study was conducted to evaluate of patient’s condition after varicocelectomy with general anesthesia Vs spinal anesthesia. Materials & Methods: In a Quasi-experimental study, 78 patients who were candidated for varicocele surgery at Emam Reza Hospital were selected sequentially. The study population was divided into two equal general and spinal anesthesia groups. All relevant data, such as demographics and clinical parameters, were registrated. Results: In this study, duration of operation, time in the operating room, first walking and feeding after operation, duration of free-pain period, pain of surgical site at 6, 12 and 24 hours after the operation, nausea and vomiting, did not show any significant difference between the two groups. In spinal anesthesia group the occurrence of headache was significantly more than general anesthesia group (P<0.03). Intraoperative erection was lower in spinal anesthesia than in the general anesthesia group (P<0.04). Conclusions: In this study, it seems that general anesthesia is useful for the decrease of postoperative complications such as headache and spinal anesthesia is useful for the decrease of intraoperative complications such as erection.