Resident of General Surgery, Kashan University of Medical Sciences and Health Services, Trauma Research Center, Kashan, Iran
Abstract
Introduction & Objective: The control of external bleeding, despite progresses in surgical science, is still one of the challenges surgeons face in saving patients’ lives. There is a research contest among the researchers in this field to introduce a more effective method. This study attempts to determine the hemostatic effect of ferric sulfate in controlling external bleeding. Materials & Methods: In this clinical trial 60 male Wistar rats were used. A 2-centimeter incision was made on each mouse’s skin and the hemostasis time was measured, using ferric sulfate with different concentrations (5.0%, 10.0%, 15.0%, 25%, and 50%) and the control method (i.e. control of bleeding by suturing). The skin tissue was assessed for pathological changes. Finally, the obtained data were entered into SPSS software and were analyzed by using Kruskal-Wallis test, Mann - Whitney, Kolmogorov – Smirnov test and also Wilcoxon signed ranks test. Results: The hemostasis time of ferric sulfate concentration groups was significantly less than that of the control group (P-value < 0.001) and the pathologic examination showed the most frequency of low grade inflammation, based on the defined pathological grading. Conclusions: Ferric sulfate may be an effective hemostatic agent in controlling an external bleeding in mouse.
Nouri,S , Amirbeigy,M , Hosseinpour,M , Abdorrahim Kashi,E , Sharif,M and Amirbeigy,M . (2013). Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012. Iranian Journal of Surgery, 21(Summer), 37-44.
MLA
Nouri,S , , Amirbeigy,M , , Hosseinpour,M , , Abdorrahim Kashi,E , , Sharif,M , and Amirbeigy,M . "Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012", Iranian Journal of Surgery, 21, Summer, 2013, 37-44.
HARVARD
Nouri S, Amirbeigy M, Hosseinpour M, Abdorrahim Kashi E, Sharif M, Amirbeigy M. (2013). 'Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012', Iranian Journal of Surgery, 21(Summer), pp. 37-44.
CHICAGO
S Nouri, M Amirbeigy, M Hosseinpour, E Abdorrahim Kashi, M Sharif and M Amirbeigy, "Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012," Iranian Journal of Surgery, 21 Summer (2013): 37-44,
VANCOUVER
Nouri S, Amirbeigy M, Hosseinpour M, Abdorrahim Kashi E, Sharif M, Amirbeigy M. Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012. Iranian Journal of Surgery. 2013;21(Summer):37-44.
