Introduction & Objective: An ectopic pregnancy (EP) is a pregnancy which occurs outside of the uterine cavity and more than 98% cases is implanted in the Fallopian tube. EP is still the most common cause of first trimester maternal deaths. The purpose of the present study was to determine the risk factors of ectopic pregnancy in women who referred to Azahra's hospital during 2001-2006. Materials & Methods: In this analytic cross-sectional study, 180 patients with EP who referred to Azahra’s hospital during 2002-2007 were studied in two groups, with and without tubal rupture. The questionnaire was designed by our researchers. Statistical analyses were performed with SPSS. Results: Frequency of ruptured EP was 44.4% (80cases). There was significant difference between the maternal age, Gravid, parity, history of infertility and history of tubal ligation with tubal rupture. However, there were no significant differences between gestational age, abortion, ectopic pregnancy history, history of pelvic or abdominal surgery, history of OCP consumption, intrauterine device usage with tubal rupture. Conclusions: Maternal age, Gravid, parity, history of infertility and tubal ligation history of EP were all significantly associated with the tubal rupture EP; so they should be considered as associated risk factors. It seems that a careful surveillance in women with these factors can help in prevention, earlier diagnosis and less complications of EP.