Comparison the Effect of Zinc Chloride and Aluminum Chloride in Controlling Liver Bleeding: an Animal Model Study

Document Type : Original Article

Authors

General Practitioner and Researcher, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Abstract
Introduction & Objective: The control of parenchymal hemorrhage especially in liver parenchyma, is still one of the challenges surgeons face saving the patients’ lives, despite progresses in surgical science. Furthermore there is a competition between the researchers in this field to introduce a more effective method. This study aimed at comparing the hemostatic effect of zinc chloride and aluminum chloride on controlling the bleeding from liver parenchymal tissue. Materials & Methods: In this animal model study, 60 male Wistar rats were used. A length of two cm and a depth of half a cm incision was made on each mouse’s liver and the hemostasis time was measured, using zinc chloride and aluminum chloride of different concentrations (15%, 25%, and 50%). Finally, the collected data were entered into SPSS software and analyzed using the one-way Anova test. Results: In all groups we had complete hemostasis. The hemostasis time of zinc chloride concentration groups was significantly less than that of the aluminum chloride group. Conclusions: Zinc chloride is more effective than aluminum chloride, as a hemostatic agent, in controlling liver hemorrhage, in our animal model study.

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