Introduction & Objective: The best method for inguinal hernia repair is matter of debate. The knowledge of efficacy and complications of each method would help to make better decisions. Accordingly, in this study the outcomes and complications of Bassini and McVay methods, both involving mesh were compared in the repair of inguinal hernia. Materials & Methods: In this randomized clinical trial, 200 patients, who were candidates for the repair of inguinal hernia, were selected and by using block randomization method were assigned to undergo either McVay method with prolene mesh (6 in 11 cm) or Bassini method with prolene mesh. The patients were followed up to 12 months for complications, recurrence, and early and late postoperative pain. Results: The frequency of complications was alike between the two groups (P > 0.05). In Bassini and McVay groups 2.9% and one percent had recurrence, respectively, without significant difference (P > 0.05). The mean duration for returning to job was 13.8 and 14.1 days in Bassini and Mcvay groups, respectively, without significant differences (P > 0.05). The mean pain severity was 4.4 and 4.2 days in Bassini and McVay methods, respectively, without significant difference (P > 0.05). In the one-year follow-up, the pain was seen in 34.2% and 10% in Bassini and McVay methods, respectively (P= 0.001) which was a significant differences, but the severity of pain was similar (P > 0.05) with its mean 2.1 and 1.9 in Bassini and McVay methods, respectively. Conclusions: Totally, according to the obtained results, it may be concluded that both McVay and Bassini methods, with mesh, had good efficacy and the recurrence, pain and complications were alike between the two groups and were at the acceptable level.