Professor of Neurosurgery, Tehran University of Medical Sciences and Health Services, Sina Hospital, Tehran, Iran
Abstract
Introduction & objective: The third common primary intracranial tumors are pituitary adenomas. Atypical pituitary tumors are characterized by MIB-1>3% & significant P53 nuclear staining. The aim of this study is to evaluate the relationship of the mutant P-53 & MIB-1 level with the outcome of these tumors. Materials & Methods: This Cohort study is conducted in both retrospective & prospective phases from April 2013 to October 2015, 83 patients were enrolled, and inclusion criteria were presence of radiological, clinical or endocrinologic evidence of functional or non-functional pituitary adenomas. Besides, all the patients underwent surgery, whether trans-sphenoidal or trans-cranial, for evacuation of adenomas. Follow-up radiologic and clinical evaluation were done 6 weeks, 6months, and one year after the surgery in all the cases. Results: The non-functional tumors were significantly more aggressive (82.2% versus 55.3% in functional adenomas) (P=0.008). No significant relationship was found between outcome MIB-1 & P53 levels (P=0.49, P=0.834 respectively). On the other hand, invasiveness was significantly related to outcome (39 patients (84.7%) with unaccepted outcome and 19 (51.3%) cases with accepted outcome were invasive, P=0.001). Conclusions: Among invasiveness & MIB-1 & P-53 level, the role reliable prognostic factors for anticipating the outcome seems to be invasiveness and the other factors can be just assumed as confounder factors.
Shirani BidAbadi,M , Amirjamshidi,A , Karimi Yarandi,K , Moradi Tabriz,H , Hossaini,S and Ghazi Mirsaeed,S . (2016). Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas. Iranian Journal of Surgery, 24(Summer), 20-30.
MLA
Shirani BidAbadi,M , , Amirjamshidi,A , , Karimi Yarandi,K , , Moradi Tabriz,H , , Hossaini,S , and Ghazi Mirsaeed,S . "Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas", Iranian Journal of Surgery, 24, Summer, 2016, 20-30.
HARVARD
Shirani BidAbadi M, Amirjamshidi A, Karimi Yarandi K, Moradi Tabriz H, Hossaini S, Ghazi Mirsaeed S. (2016). 'Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas', Iranian Journal of Surgery, 24(Summer), pp. 20-30.
CHICAGO
M Shirani BidAbadi, A Amirjamshidi, K Karimi Yarandi, H Moradi Tabriz, S Hossaini and S Ghazi Mirsaeed, "Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas," Iranian Journal of Surgery, 24 Summer (2016): 20-30,
VANCOUVER
Shirani BidAbadi M, Amirjamshidi A, Karimi Yarandi K, Moradi Tabriz H, Hossaini S, Ghazi Mirsaeed S. Prognostic Significance of Mutant P-53 & MIB-1 Level upon the Outcome of Patients Underwent Operation for Various Pituitary Adenomas. Iranian Journal of Surgery. 2016;24(Summer):20-30.
