Evaluation of the Effectiveness of Sodium Hyaluronate, Sesame Oil, Honey and Silver Nanoparticles in Preventing Postoperative Surgical Adhesion Formation

Khorshidi, HR; Kamalpour, GhR; Hosseini Panah, M

Evaluation of the Effectiveness of Sodium Hyaluronate, Sesame Oil, Honey and Silver Nanoparticles in Preventing Postoperative Surgical Adhesion Formation

Document Type : Original Article

Authors

HR Khorshidi ¹

GhR Kamalpour ²

M Hosseini Panah ³

¹ Assistant Professor, Thoracic Surgery Department, Hamadan University of Medical Sciences, Baisat Hospital

² General surgeon, Hamedan University of Medical Sciences, Baisat Hospital

³ Professor of Anatomy, Hamedan University of Medical Sciences, Besat Hospital, Hamedan, Iran

Abstract

Introduction & Objective: Postoperative surgical adhesion is a common consequence of intraperitoneal surgery which may lead to several complications such as adhesive small bowel obstructions, chronic abdominopelvic pain, and female infertility making a significant adverse impact on health care costs. Many efforts have been made aiming to decrease the rate of postoperative surgical adhesion formation. We conducted the present experimental study aiming to evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. Materials & Methods: Our study was conducted in Hamadan University of Medical Sciences, Hamadan, Iran during 2015 and 2016. Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. They were housed in 21°C temperature and 60% ± 5 humidity. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. Statistical analyses were performed by using SPSS software (IBM SPSS Statistics for Windows, Version 20.0, IBM Corp., Armonk, NY, USA). Quantitative and qualitative data were analyzed using the Kruskal-Wallis and Mann-Whitney U test, respectively. Statistical significance was defined by (P < 0.05). Results: The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. Conclusions: Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.

Keywords

Hyaluronate

Sesame Oil

Surgical Adhesion

Silver Nanoparticles

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