The Use of Maggot Therapy and Tissue Engineering for Wound Chronic Treatment

Sadeghabadi, A; Najmedin, N; Asefneghad, A

The Use of Maggot Therapy and Tissue Engineering for Wound Chronic Treatment

Authors

A Sadeghabadi ¹

N Najmedin ²

A Asefneghad ²

¹ Researcher of Medical Engineering, Department of Medical Science and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran

² Assistant Professor, Department of Biomedical Engineering, Islamic Azad University, Tehran Science and Research Branch, Faculty of Medical Sciences and Technologies

Abstract

Maggot therapy is mentioned in holy books. After the introduction of antibiotics to the market, a long period of delay occurred in using maggot therapy method. In recent years, due to resistance of infectious agents against antibiotics, there has been a good return to this method. In 1999, WHO confirmed this science and included it in its remedial policies. Maggot therapy was approved by FDA in 2004. Tissue engineering means development and change in experimental growth of cells in tissues or limbs, in order to substitute or heal the damaged part of the body. The main problem of serious wounds is the risk of infection, their depths and loss of tissue. Integrated use of maggot therapy and tissues engineering is a bridge between two ancient and modern methods which is very effective for curing diabetic wounds and bedsore. Due to high probability of success in this method, development and use of the above-mentioned method is highly recommended and it is necessary to use this method in our country widely.

Keywords

Maggot Therapy

Tissue Engineering

Infection

Diabetic Wound

Bedsore

1. Sherman RA, Hall MJR, Thomas S: Medicinal maggots: an ancient remedy for some contemporary afflictions. Annu Rev Entomol. 45: 55-81. 2000.

2. Ronald A.sherman" Maggot Therapy Takes US back to the future of wound care: New and improved Maggot Therapy for the 21st century" Journal of Diabetes Science and Technology. Mar 2009.

3. Gemma Jones" Maggot-therapy in veterinary medicine" Research in Veterinary Science, volume 85, October 2008. ELSEVIER.

4. Ronald A. Sherman "Maggot Therapy for Treating Diabetic foot ulcers unresponsive to conventional Therapy" Diabetes care. August 2016.

5. Mumcuoglu KY, Ingber A, Gilead L, Stessman J, Friedmann R, Schulman H, Bichucher H,
Ioffe-Uspensky I, Miller J, Galun R, Raz I: Maggot therapy for the treatment of diabetic foot ulcers. Diabetes Care. 21(11): 2030-31. 1998.

6. Sherman RA, Wyle F, Vulpe M.1995. Maggot debridement therapy for treating pressure ulcers in spinal cord injury, patients. J. Spinal cord, Md. 18:
71-74. 7.

7. Sherman, RA, Wyle, F, Vulpe, M: Maggot Debridement Therapy for treating pressure ulcers in spinal cord injury patients. Journal of Spinal Cord Medicine, 18(2): 71-74. 1995.

8. Mumcuoglu KY, Lipo M, Ioffe Uspensky I, Miller J, Galun R. [Maggot therapy for gangrene and osteomyelitis] (in Hebrew). Harefuah 1997; 132:
323-5, 382.

9. Xinjuan sun "A systematic review of maggot debridement therapy for chronically infected wounds and ulcers" International Journal of Infections Diseases. Volume 25, August 2014. ELSEVIER.

10. Sherman RA, Peehter EA.1988.maggot therapy: a review of the therapeutic applications of fly larve in human medicine, especially for treating osteomyelitis. Med. vet. Entomol. 2: 225-30.

11. Cazander G, van Veen KE, Bernards AT, Jukema GN (April 2009). "Do maggots have an influence on bacterial growth? A study on the susceptibility of strains of six different bacterial species to maggots of Lucilia sericata and their excretions/secretions". J Tissue Viability. doi: 10.1016/j.jtv.2009.02.005. PMID 19362001.

12. Daeschlein G, Mumcuoglu KY, Assadian O, Hoffmeister B, Kramer A (2007). "In vitro antibacterial activity of Lucilia sericata maggot secretions". Skin Pharmacol Physiol 20 (2): 112-5. doi: 10.1159/000097983. PMID 17167275.

13. Jaklic D, Lapanje A, Zupancic K, Smrke D, Gunde-Cimerman N (May 2008). "Selective antimicrobial activity of maggots against pathogenic bacteria". J. Med. Microbiol. 57 (Pt 5): 617-25. doi: 10.1099/jmm.0.47515-0. PMID 18436596.

14. Reames MK, et al. The use of maggots in wound debridement. Annals of Plastic Surgery. 21: 388, 1988.

15. Mumcuoglu KY. Clinical applications for maggots in wound care. American Journal of Clinical Dermatology 2: 219-227, 2001.

16. Sherman RA: Maggot Therapy. Infection Control in Long-Term Care Facilities Newsletter (APIC). 6(3): 5. 1995.

17. Thomas S, Jones M, Shutler S, Jones S. Using larvae in modern wound management. J Wound Care 1996; 5:60-9.

18. Sherman RA: Maggot therapy: the last five years. Bulletin of the European Tissue Repair Society. 7(3): 97-98; 2000.

19. Namias N, Varela E, Varas RP, Quintana O, and Ward CG: Biodebridement: a case report of maggot therapy for limb salvage after fourth-degree burns. J Burn Care Rehabil 21 (3): 254-257, 2000.

20. Sheila Macneil "Biomaterials for tissue engineering of skin" Materialstoday, Voiume 11, May 2008.

21. Sophie Bottcher-Haberzeth "Tissue engineering of skin" BURNS, volume 36, June 2010.

22. Steven T. Boyce and Andrea L. Lalley, Tissue engineering of skin and regenerative medicine for wound care, Burns & Trauma (2018).