Introduction & Objective: Considering that in previous studies, the role of depression before surgery with chronic and acute pain after surgery has not been accurately reported and the contribution of this psychological factor to pain (acute and chronic) after breast cancer surgery is unclear, the purpose The purpose of this study is to determine the effects of depression before surgery on acute and chronic pain after breast cancer surgery. Materials & Methods: This study was conducted as a systematic review and meta-analysis. Searching for articles in Medline, EMBASE, CINAHL, Scopus, Web of Science, Iranian Mag and SID databases with keywords "pain or chronic pain or acute pain or pain after surgery" and "depression" and "breast cancer, breast surgery" , breast" was done. Forest and funnel plots were used to analyze the results. Results: The results indicated that the relationship between pre-surgery depression and short-term pain intensity (7 days to 3 months) (0.03-0.45) CI 95%: 0.24 - 59%- = I2 and P = 0.12), pain three to six months after surgery (0.07-23) 0.15: CI95% - 70% = I2 and P ≥ 0.01) and chronic pain (12 months) (0.12-22 0.17: CI95% - 28% I2 and P = 0.19 are significant. Conclusions: Depression before surgery increases the risk of acute and chronic pain after surgery.