Introduction & Objective: Hydatid cyst is a type of parasitic infection that causes damage to liver, lung and other body organs. A person who gets a hydatid cyst usually experiences severe complications and cysts develop in his body that must be treated as soon as possible. This study was conducted with the aim of epidemiological investigation of hydatid cyst surgery patients in hospitals of Qom province during 2001-2016. Materials & Methods: This study was conducted in a descriptive-cross-sectional manner. The files of all patients with hydatid cysts operated on in educational and medical centers of Qom city (public and private) were examined by census. Then, the information related to the desired variables (age, sex, place of residence, occupation, involved organ, disease recurrence, serology and ultrasound for cyst) were recorded in the patient information registration form and then subjected to statistical analysis. Results: In this study, 72 women (51.8%) and 67 men (48.2%) were examined. The average age of the patients was 39.58 ± 15.18 years. The length of hospitalization of the patients was 5.58 ± 3.46 days. The most diagnostic method was CT scan 70 (50.4%) and the most serological method used for indirect hemagglutination patients was 124 cases (90.5%). The most involved organ in patients was the right lobe of the liver in 68 cases (48.9%). No significant statistical relationship was found between age, gender, occupation and location of hydatid cyst (P > 0.05). Conclusions: Considering the importance of hydatid cyst disease in Qom city, it is felt necessary to conduct more comprehensive and updated studies. Also, it is felt necessary to educate and inform the society about this disease and to control and stop the parasite cycle.