Comparison of Serum Ferritin Levels in Children with Iron Deficiency Anemia with and without Early Childhood Caries Requiring Surgery: A Systematic Review and Meta-Analysis

Rezaei, Y; Daneshpooy, M

Comparison of Serum Ferritin Levels in Children with Iron Deficiency Anemia with and without Early Childhood Caries Requiring Surgery: A Systematic Review and Meta-Analysis

Authors

Y Rezaei ¹

M Daneshpooy ²

¹ Assistant Professor of Dental Prosthodontics, Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences

² Assistant Professor of Restorative Dentistry Department of Restorative Dentistry, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background and Objective: Conflicting results in the literature indicate that there is no definitive association between ferritin levels and dental caries in childhood. However, several studies have suggested a close relationship between iron deficiency anemia and early childhood caries requiring surgical intervention. Given the correlation between ferritin levels and iron deficiency anemia, as well as the strong connection between iron deficiency anemia and early childhood caries in children needing surgery, this study aims to compare serum ferritin levels in children with iron deficiency anemia with and without dental caries that necessitate surgical treatment. Materials & Methods: This study was a systematic review and meta-analysis conducted according to the PRISMA guidelines. The databases searched included Scopus, ProQuest, PubMed, and ISI Web of Science for studies published in English, and Magiran and SID for studies published in Persian. The defined keywords for this study were used in the searches across these databases. Results: The results of the meta-analysis indicated that serum ferritin levels in children with early childhood caries requiring surgery were significantly lower than those in healthy children (P = 0.008, 95% CI: -0.230 to -0.446). Conclusion: Early childhood caries requiring surgical intervention leads to poor dietary habits, which may be associated with anemia and low ferritin levels. Our study's findings clearly demonstrate that early childhood caries results in a significant reduction in serum ferritin levels.

Keywords

Early Childhood Caries

Child

Iron Deficiency Anemia

Ferritin

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