Background and Objective: Thyroid malignancy is a fairly common cancer which had an increasing rate of incidence in the recent years. This disease presents itself as nodular lesions. Thyroidectomy is a standard procedure for managing patients with thyroid malignancies. This disease is also prevalent in the population of southern Iran and makes up the majority of the endocrine malignancies. Due to the importance of the disease, in this study we aimed evaluate the demographic and clinical characteristics of patients who underwent thyroidectomy in southern population of Iran. Materials & Methods: This cross-sectional study uses the data extracted from Iranian National Thyroid Surgery Registry (INTSR). All the patients who underwent thyroidectomy during 2023 and 2024 and did not fulfill any exclusion criteria are enrolled in the study. Demographic data, medical history, familial history, laboratory data, and details of their surgery are extracted and evaluated. Results: Of all the 1409 patients in the study, 274 (19.4%) were males and 1135 (80.6%) were females. The mean age of the patients was 44.33±12.96. the most common surgery was total thyroidectomy (13.7 (92.8%0). The most common pathologic findings after surgery were PTC classic type (32.2%), MNG (19.7%), PTC follicular type (17.7%), PTMC (15.1%), benign nodular hyperplasia (14.7%), Hashimoto (2.6%), parathyroid adenoma (2.4%), graves’ disease (1.8%), Hurthle cell carcinoma (1.4%), and MTC (0.7%), respectively. The most common FNA findings were as follows: PTC (43.9%), benign findings (17.1%), AUS/FLUS (7.9%), MNG (7.9%), and graves’ disease (2.3%), respectively. Conclusion: In this study, the demographic and clinical data of patients who underwent thyroidectomy is evaluated. PTC was seen to be the most prevalent pathology among the patients. The majority of patients who underwent thyroidectomy were women. The most common FNA result was also PTC. Further studies are required to deepen our understanding of risk-factors and predisposing factors of thyroid malignancies and improve the treatment quality.