A Review of the Role of Microbiomes in Breast Cancer: Challenges and Opportunities

Document Type : Review Article

Authors

1 Professor of General Surgery, Tehran University of Medical Sciences, Tehran Hospital

2 Department of Gynecology and Obstetrics, Bentolhoda Hospital, North Khorasan University of Medical Sciences, Bojnord, Iran

3 Master’s Degree in Artificial Intelligence

Abstract
This paper explores the impact of the microbiome on breast cancer (BC), one of the most prevalent and dangerous types of cancer in women. While factors such as obesity and family history are recognized as risk factors, the microbiome has emerged as a novel and potential contributor to the onset and prevention of BC. The microbiomes of the breast, gut, and oral cavity can influence estrogen metabolism and inflammation, potentially facilitating the development of cancer. Additionally, research indicates that probiotics may play a role in inhibiting BC development. Given that the microbiome can affect treatment response and its side effects, monitoring microbiome composition and developing new therapeutic strategies could aid in the prevention and improvement of BC treatment outcomes. Due to the sensitivity and complexity of this topic, further research is necessary to gain a more precise understanding of the microbiome's role in BC.

Keywords


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