Journal Title: بهار 86
Article title: Investigation of the Effects of Using Intravenous Tranexamic Acid on the Reduction of Blood Loss in Lumbar Hernial Disc Resection with Inhalation and Total Intravenous Anesthesia

Article PDF File:
Page From: 95 To: 101      
Article abstract:
Introduction & Objective: Tranexamic acid is a synthetic antifibrinolytic drug that reduces bleeding and transfusion requirements in cardiac surgery and total knee arthroplasty. In this study, we evaluated the efficacy of the prophylactic tranexamic acid to reduce intraoperative bleeding and improving visual field of the surgeon in patients undergoing lumbar hernial disc resection, anesthetize with two different methods of inhalation or total intravenous anesthesia. Materials & Methods: Eighty percent patients in ASA class I-II were randomized into 4 groups. In group 1, anesthesia was achieved by total intravenous anesthesia and tranexamic acid was administered too. Other groups were: group 2, anesthesia by total intravenous anesthesia without tranexamic acid, group 3, anesthesia by halothane and tranexamic acid was administered and in group 4, anesthesia by halothane without tranexamic acid was achieved. Blood loss and surgeon's satisfaction were registered. Results: The amount of blood loss in each group was as follow: Group 1: 267.1  177.3 ml; group 2: 656  411.6 ml Group 3: 357  307.2 ml; group 4: 550  406.7 ml The least bleeding was recorded in group 1 which had a significant difference with group 2 (p=0.007) and group 4 (p=0.04) that tranexamic acid was not administered. Blood loss in group 2 and 4 was identical and had no significant difference (p= 0.3). Surgeon's highest satisfaction was with group 1. No complications were registered in 4 groups. Conclusions: We concluded that administration of prophylactic tranexamic acid in patients undergoing hernial disc resection has the potential to reduce intraoperative bleeding and improving visualization of the surgical field especially when administered with total intravenous anesthesia. The method of anesthetic management had no effect.
Article KeyWords:
Tranexamic Acid, Halothane, Total Intravenous Anesthesia, Propofol, Hernial Disc Resection
Article Authors:

	دكتر رضا جلائيان‌تقـدمي	First Author	r-jalaeian@mums.ac.ir
	دكتـر حسين مشهدي‌نژاد	Other Author
	دكتر آرش پيـوندي	Other Author