Journal Title: بهار 88
Article title: Determination of the Macroscopic Effect of Kiwi Fruit on Wound Healing in Rats (A New Effective Drug for the Treatment of Deep Chronic Wounds)

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Article abstract:
Introduction & Objective: Actinidia deliciosa (kiwi fruit) is used as a meat tenderizer. It acts rapidly and efficiently to soften meat and even to crush it, if it is allowed to work for more than a few hours. Observing this effect and considering the lack of studies addressing this subject in the literature, the authors decided to investigate the use of this natural remedy in an animal model. Materials & Methods: Thirty-five male rats were divided randomly into three groups. Under general anesthesia, a limited standard 3rd degree burn was produced on the back of each rat. For the intervention group (G1, 15 rats), the wounds were covered with fresh kiwi fruit; for control groups 2 and 3 (G2, 15 rats; G3, 5 rats), the dressing was a neutral ointment (Emulsifier the 1220). Weekly wound observations were documented for all groups. Groups 1 and 2 were sacrificed on the day 20th, and the group 3 was kept alive until complete eschar separation. The wounds of groups 1 and 2 were excised in full thickness and underwent to microscopic evaluation. Results: On the day 20th, all eschars had become detached and fallen off in the intervention group (G1), whereas in groups G2 and G3 the eschars were still firmly attached to the base of the wounds (except in two rats of group G2). This finding was statistically significant (P <0.001). The average wound surface area in group G1 was 212.3869±88.80938 mm2, whereas in the group G2 it was 388.4749±140.6967 mm2, Thus, the wound surface area was significantly (P < 0.001) smaller in the intervention group. The eschars in the group G3 were separated spontaneously between days 30th and 42nd, while in all the rats of the kiwi-treated group, this phenomenon occurred before the day 20th. The pathologic study revealed no considerable differences between groups G1 and G2 (P < 0.05). Conclusions: Debridement, neo-epithelialization and scar contraction were faster in the kiwi-treated group than in the untreated group. Following rapid enzymatic debridement, healing appeared to progress normally, with no evidence of damage to the adjacent healthy tissue.
Article KeyWords:
Kiwi Fruit, Enzymatic Debridement, Wound Healing
Article Authors:

	دكتر فرهاد حافظي	First Author	info@drhafezi.com
	دكتر حميد علمي‌راد	Other Author
	دكتر ميرسپاس پدرام	Other Author