Journal Title: پاییز 88
Article title: Evaluation of the Pyridoxine Effect in Nausea and Vomiting of Early Pregnancy

Article PDF File:
Page From: 56 To: 63      
Article abstract:
Introduction & Objective: Nausea and vomiting in early pregnancy are common symptoms which are a great burden either economically or psychologically on the pregnant women and her family. Considering the fact that, pregnant women do not seek appropriate medical treatment because of their concern of drug's side effects on fetus, it would be useful to administrate vitamins, which are accepted as safe drugs, for the first line treatment. Our Purpose was to determine the effectiveness of Pyridoxine for nausea and vomiting of pregnant women with less than 16 weeks of gestational age. Materials & Methods: During the winter of 2006, 70 pregnant women with less than 16 weeks of gestational age, who had attended a private clinic and four urban Health Centers in Rasht, were randomly divided in to two groups to receive either oral Pyridoxine 40 mg per day or placebo during five days, in a double- blind fashion. Patients graded the severity of their nausea by a visual analog scale over 24 hours before the treatment and then during the five days of treatment. They also recorded the number of vomiting episodes over the previous 24 hours before the treatment and during the five days of treatment. Data was analyzed by t-test, ANCOVA, ordered logistic regression, chi-square, Mann-Witney and Wilkoxon tests. Results: There was a significant decrease in the mean of post therapy minus baseline nausea score in the pyridoxine group compared with that in the placebo group (P= 0.019 - ANCOVA). There was also a greater reduction in the mean number of vomiting episodes in the pyridoxine group (P= 0.042 - Mann witney test) Conclusions: Pyridoxine is effective in decreasing nausea and vomiting in early pregnancy and it can be administrated 40 mg per day during 3 to 4 days.
Article KeyWords:
Pregnancy, Nausea, Pyridoxine, Placebo
Article Authors:

	دكتر رويا فرجي	First Author	r_farajidarkhaneh@yahoo.com
	دكتر سيده هاجر شارمي	Other Author
	دکتر آبتين حيدرزاده	Other Author