Introduction & Objective: The aim of this study is to define the relative prevalence of, clinical and demographic state of Burger’s patients admitted to Alzahra hospital, in order to achieve a new attitude on clinical and epidemiological future of the disease. Materials & Methods: This is a descriptive analytic study based on 80 Burger’s patient profiles admitted to Alzahra hospital from 2003 to 2005. The patient information was analyzed on the bases of age, sex, involving limb, smoking, opium addiction, symptoms and duration of the disease and interventions (either medical or surgical) used. Finally the data was analyzed by X2 and Fisher’s exact test in SPSS 13 software. Results: The study demonstrated that there was a significant correlation between addiction and ulcer in patients but no significant correlation was established between the age, sex, smoking and clinical sign and symptoms of the disease. Among all patients evaluated in this study, amputation of the limb was done on 60.1%, sympathectomy on 97.6%, dural catheter on 3.8% and revascularization on 2.6%. Drugs used subsequently as medical therapy were pentoxifyelin, Aspirin, iloprost on 61.2%, 18.8% and 2.5% respectively. Conclusions: There was a significant correlation between opium addiction and ulcer and also amputation. Other studies were on accordance with our study. With early diagnosis based on history and clinical examination, we can prevent disease.